Publicaciones
P U B L I C A C I O N E S
Liver function markers and haematological dynamics during acute and chronic phases of experimental Fasciola hepatica infection in cattle treated with triclabendazole. Costa M, Saravia A, Ubios D, Lores P, da Costa V, Festari MF, Landeira M, Rodríguez-Zraquia SA, Banchero G, Freire T.Exp Parasitol. 2022 May 30;238:108285. doi: 10.1016/j.exppara.2022.108285.
Advances in the Immunomodulatory Properties of Glycoantigens in Cancer. da Costa V, Freire T.Cancers (Basel). 2022 Apr 7;14(8):1854. doi: 10.3390/cancers14081854.
Heme-Oxygenase-1 Attenuates Oxidative Functions of Antigen Presenting Cells and Promotes Regulatory T Cell Differentiation during Fasciola hepatica Infection. Costa M, da Costa V, Frigerio S, Festari MF, Landeira M, Rodríguez-Zraquia SA, Lores P, Carasi P, Freire T.Antioxidants (Basel). 2021 Dec 3;10(12):1938. doi: 10.3390/antiox10121938.
The tumor-associated Tn antigen fosters lung metastasis and recruitment of regulatory T cells in triple negative breast cancer. Festari MF, da Costa V, Rodríguez-Zraquia SA, Costa M, Landeira M, Lores P, Solari-Saquieres P, Kramer MG, Freire T.Glycobiology. 2022 Apr 21;32(5):366-379. doi: 10.1093/glycob/cwab123.
The Tn antigen promotes lung tumor growth by fostering immunosuppression and angiogenesis via interaction with Macrophage Galactose-type lectin 2 (MGL2). da Costa V, van Vliet SJ, Carasi P, Frigerio S, García PA, Croci DO, Festari MF, Costa M, Landeira M, Rodríguez-Zraquia SA, Cagnoni AJ, Cutine AM, Rabinovich GA, Osinaga E, Mariño KV, Freire T.Cancer Lett. 2021 Oct 10;518:72-81. doi: 10.1016/j.canlet.2021.06.012.
Human hydatid cyst fluid-induced therapeutic anti-cancer immune responses via NK1.1+ cell activation in mice. Berriel E, Freire T, Chiale C, Rodríguez E, Morón G, Fernández-Graña G, Crispo M, Berois N, Osinaga E.Cancer Immunol Immunother. 2021 Dec;70(12):3617-3627. doi: 10.1007/s00262-021-02948-x.
A biotechnological tool for glycoprotein desialylation based on immobilized neuraminidase from Clostridium perfringens. Bidondo L, Landeira M, Festari F, Freire T, Giacomini C.Biochem Biophys Rep. 2021 Mar 2;26:100940. doi: 10.1016/j.bbrep.2021.100940.
Immobilized peptide-N-glycosidase F onto magnetic nanoparticles: A biotechnological tool for protein deglycosylation under native conditions. Bidondo L, Festari F, Freire T, Giacomini C.Biotechnol Appl Biochem. 2022 Feb;69(1):209-220. doi: 10.1002/bab.2099.
The cytosolic tryparedoxin peroxidase from Trypanosoma cruzi induces a pro-inflammatory Th1 immune response in a peroxidatic cysteine-dependent manner. López L, Chiribao ML, Girard MC, Gómez KA, Carasi P, Fernandez M, Hernandez Y, Robello C, Freire T, Piñeyro MD.Immunology. 2021 May;163(1):46-59. doi: 10.1111/imm.13302.
Eosinophils Control Liver Damage by Modulating Immune Responses Against Fasciola hepatica. Frigerio S, da Costa V, Costa M, Festari MF, Landeira M, Rodríguez-Zraquia SA, Härtel S, Toledo J, Freire T.Front Immunol. 2020 Sep 18;11:579801. doi: 10.3389/fimmu.2020.579801.
Irritable bowel syndrome in celiac disease - relationships to celiac disease antibodies and levels of pro-inflammatory cytokines. Olano C, López V, Freire T, Rodríguez X, Pontet Y, Alemán A, Rodríguez N, Rovira L, Trucco E, Osinaga E, Cohen H, Quigley EM.Rev Gastroenterol Peru. 2020 Apr-Jun;40(2):127-135.PMID: 32876628
Evaluation of the Immune Regulatory Properties of Dendritic Cells During Fasciola hepatica Infection. Freire T.Methods Mol Biol. 2020;2137:181-190. doi: 10.1007/978-1-0716-0475-5_13.PMID: 32399929
Resistance to Haemonchus contortus in Corriedale sheep is associated to high parasite-specific IgA titer and a systemic Th2 immune response. Escribano, C., Saravia, A., Costa, M., Castells, D., Ciappesoni, G., Riet-Correa, F., Freire, T. Scientific Reports, DOI : 10.1038/s41598-019-55447-6 SREP-19-23610 pdf
Novel and Selective inactivators of Triosephosphate isomerase 2 with anti-trematode activity. Ferraro, F., Corvo, I., Bergalli, L., Ilarraz, A., Cabrera, M., Gil, J., Susuki, BM., Caffrey, C., Timson, DJ., Robert, X., Guillon, C., Freire, T., Álvarez, G. Scientific Reports, DOI : 10.1038/s41598-019-55447-6 SREP-19-23610 pdf
S-Layer Glycoprotein form Lactobacillus kefiri exerts its immunostimulatory activity through glycan recognition by Mincel. Malamud M, Carasi P, Assandri MH, Freire T, Lepenies B, Serradell MLÁ. Front Immunol. 2019 Jun 26;10:1422. doi: 10.3389/fimmu.2019.01422. eCollection 2019. pdf
Immobilization of beta-galactosidase and alpha-mannosidase onto magnetic nanoparticles: A strategy for increasing the potentiality of valuable glycomic tools for glycosylation analysis and biological role determination of glycoconjugates Rodriguez E , K. FRANCIA , BROSSARD, N , Garcia Vallejo JJ , Kalay H , van Kooyk Y , FREIRE, T., Giacomini C Enzyme and Microbial Technology, v.: 117 p.:45 - 55, 2018 pdf
Heme-Oxygenase-1 Expression Contributes to the Immunoregulation Induced by Fasciola hepatica and Promotes Infection. CARASI, P , RODRIGUEZ, E , DA COSTA, V , FRIGERIO, S , BROSSARD, N. , NOYA, V , ROBELLO, C , ANEGóN, I , FREIRE, T. Frontiers in Immunology, v.: 8 p.:883 - 893, 2017 pdf
S-layer glycoprotein from Lactobacillus kefiri CIDCA 8348 enhances macrophages response to LPS in a Ca+2-dependent manner. MALAMUD, M , CARASI, P , FREIRE, T., SERRADELL, M Biochemical and Biophysical Research Communications, v.: 495 1 , p.:1227 - 1232, 2017 pdf
Fasciola hepatica Immune Regulates CD11c+ Cells by Interacting with the Macrophage Gal/GalNAc Lectin (Completo, 2017) RODRIGUEZ, E , CARASI, P , FRIGERIO, S , DA COSTA, V , VAN VLIET, S , NOYA, V , BROSSARD, N. , VAN KOOYK, Y , GARCíA-VALLEJO, J , FREIRE, T., Frontiers in Immunology, 2017 DOI: 10.3389/fimmu.2017.00264 pdf
Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic CellSpecific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy. RODRIGUEZ, E , KALAY, H , NOYA, V , BROSSARD, N. , GIACOMINI, C. , VAN KOOYK, Y , GARCíA-VALLEJO, J , FREIRE, T., Scientific Reports, 7:46748. doi: 10.1038/srep46748, 2017 pdf
A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1polarizing activity. NOYA, V , BROSSARD, N. , RODRIGUEZ, E , DERGAN-DYLON S , CARMONA, C , RABINOVICH G , FREIRE, T., Scientific Reports, 7:40615. doi: 10.1038/srep40615 2017 pdf
Revisiting the human polypeptide GalNAc-T1 and T13 paralogs. FESTARI, F , TRAJTENBERG F , BEROIS, N , PANTANO S , REVOREDO L , KONG Y , SOLARISAQUIERES P , NARIMATSU Y , FREIRE, T., BAY, S , ROBELLO, C , BERNARD J , GERKEN TA , CLAUSEN H , OSINAGA, E Glycobiology (E), v.: 27 2017 pdf
Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers UBILLOS, L , FREIRE, T., BERRIEL, E , CHIRIBAO, ML , CHIALE, C. , FESTARI, MF , MEDEIROS, A , MAZAL, D , RONDAN, M , BOLLATI-FOGOLíN M , RABINOVICH, GA , ROBELLO, C , OSINAGA, E International journal of cancer. v.: 138 7 , p.:1719 - 1731, 2016 pdf
A mucin-like peptide from Fasciola hepatica induces parasite-specific Th1-type cell immunity NOYA, V , BROSSARD, N. , BERASAIN, P. , RODRIGUEZ, E , CHIALE, C. , MAZAL, D , CARMONA, C , FREIRE, T. Parasitology Research (E), v.: 115 3, p.:1053 - 1063, 2016 pdf
MUC5B silencing reduces chemo-resistance of MCF-7 breast tumor cells and impairs maturation of dendritic cells GARCíA, EP , TISCORNIA, I , LIBISCH, G , TRAJTENBERG, F , BOLLAT-FOGOLíN, M , RODRIGUEZ, E , NOYA, V , CHIALE, C. , BROSSARD, N. , ROBELLO, C , OSINAGA, E , FREIRE, T. International Journal of Oncology, v.: - 2016 pdf
Glycans from Fasciola hepatica Modulate the Host Immune Response and TLR-Induced Maturation of Dendritic Cells RODRIGUEZ, E , NOYA, V , CERVI, L. , CHIRIBAO, ML , BROSSARD, N. , CHIALE, C. , CARMONA, C , GIACOMINI, C. , FREIRE, T. PLoS Neglected Tropical Diseases, v.: 9 12, 2015 pdf
Mucin-like peptides from Echinococcus granulosus induce antitumor activity. NOYA, V , BAY, S , FESTARI, F , GARCIA, E , RODRIGUEZ, E , CHIALE, C. , GANNEAU, C , BALEUX, F , ASTRADA, S , BOLLATI-FOGOLIN, M , OSINAGA, E , FREIRE, T. International Journal of Oncology, v.: 43 3 , p.:775 - 784, 2013 pdf
Antitumor Activity of Human Hydatid Cyst Fluid in a Murine Model of Colon Cancer BERRIEL, E , RUSSO, S , MONIN, L , FESTARI, F , BEROIS, N , FERNANDEZ, G , FREIRE, T., OSINAGA, E The Scientific World Journal, v.: 230176 2013 pdf
The sweet-side of tumor immunotherapy FREIRE, T., OSINAGA, E Immunotherapy, v.: 4 7 , p.:719 - 734, 2012 pdf
Tn Glycosylation of the MUC6 Protein Modulates Its Immunogenicity and Promotes the Induction of Th17-biased T Cell Responses. FREIRE, T., LO-MAN, R , BAY, S , LECLERC, C Journal of Biological Chemistry, v.: 286 10 , p.:7797 - 7811, 2011 pdf
Glycosidic Tn-based vaccines targeting dermal DC favor germinal center B-cell development and potent antibody responses in the absence of adjuvant FREIRE, T., ZHANG, X , DÉRIAUD, E , GANNEAU, C , VICHIER-GUERRE, S , AZRIA, E , LAUNAY, O , LO-MAN, R , BAY, S , LECLERC, C Blood,v.: 116 18 , p.:3526 - 3536, 2010 pdf
A novel clinically-relevant animal model to study galectin-3 and its ligands during colon carcinogenesis HILL, M , MAZAL, D , BIRON, V , PEREIRA L , UBILLOS, L , BERRIEL, E , AHMED, H , FREIRE, T., RONDAN, M , VASTA, G , LIU, F , IGLESIAS, MM , OSINAGA, E Journal of Histochemistry and Cytochemistry, v.: 58 6 , p.:553 - 565, 2010 pdf
Carbohydrate antigens: synthesis aspects and immunological applications in cancer FREIRE, T. BAY, S , VICHIER-GUERRE, S , LO-MAN, R , LECLERC, C Mini Reviews in Medicinal Chemistry, v.: 6 p.:1357 - 1373, 2006 pdf
ppGalNAc-T6 mRNA as a potential new marker for detection of bone marrow disseminated breast cancer cells. FREIRE, T., BEROIS, N , SÓÑORA, C , VARANGOT, M , BARRIOS, E , OSINAGA, E International Journal of Cancer, v.: 119 p.:1383 - 1388, 2006 pdf
Enzymatic large-scale synthesis of MUC6-Tn glycoconjugates for anti-tumor vaccination FREIRE, T. , LO-MAN, R , PILLER, F , PILLER, V , LECLERC, C , BAY, S Glycobiology, v.16.:390 - 401, 2006 pdf
Efficient monitoring of enzymatic conjugation reaction by surface-enhanced laser desorption/ionization time of flight mass spectrometry (SELDI-TOF MS) for process optimization. FREIRE, T , DALAYER, J , BAY, S Bioconjugate Chemistry, v.: 17 p.:559 - 564, 2006 pdf
Molecular basis of incomplete O-glycan synthesis in breast cancer cells: putative role of MUC6 in Tn antigen expression. FREIRE, T., BAY, S , VON MENSDORFF-POUILLY, S , OSINAGA, E Cancer Research, v.: 65 p.:7880 - 7887, 2005 pdf
Characterization of a UDP-N-acetygalactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus FREIRE, T., FERNANDEZ, C. , CHALAR, C. , MAIZELS, R.M. , ALZARI, P.M. , OSINAGA, E , ROBELLO, C. Biochemical Journal, v.: 382 p.:501 - 510, 2004 pdf
Sialyl-Tn antigen expression and O-linked GalNAc-Thr synthesis by Trypanosoma cruzi FREIRE, T., ROBELLO, C , SOULE, S , FERREIRA, A , OSINAGA, E Biochemical and Biophysical Research Communications, v.: 312 p.:1309 - 1316, 2003 pdf
Mucin type O-glycosylation in Fasciola hepatica: characterization of carcinoma associated Tn and sialyl-Tn antigens and evaluation of ppGalNAc-transferase activity FREIRE, T., CASARAVILLA, C , CARMONA, C. , OSINAGA, E International Journal for Parasitology, v.: 33 p.:47 - 56, 2002 pdf